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Published ahead of print on May 5, 2005, doi:10.1164/rccm.200411-1486OC
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American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 329-333, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200411-1486OC

Original Article

A Disintegrin and Metalloprotease 33 Polymorphisms and Lung Function Decline in the General Population

Cleo C. van Diemen, Dirkje S. Postma, Judith M. Vonk, Marcel Bruinenberg, Jan P. Schouten and H. Marike Boezen

Departments of Epidemiology and Bioinformatics, Pulmonology, and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands

Correspondence and requests for reprints should be addressed to H. Marike Boezen, Ph.D., UMCG, Department of Epidemiology and Bioinformatics, Room P1.129, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. E-mail: h.m.boezen{at}med.umcg.nl

Rationale: A disintegrin and metalloprotease 33 (ADAM33) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excessive decline of lung function in individuals with asthma. Objectives: To assess whether SNPs in ADAM33 are associated with accelerated lung function loss in the general population and with chronic obstructive pulmonary disease (COPD). Methods: DNA was collected from subjects of the Vlagtwedde–Vlaardingen cohort participating in the last survey in 1989–1990 after a follow-up of 25 years. Information was collected every 3 years, including lung function measurements. We defined COPD as GOLD stage 2 or higher at the last survey. A total of 1,390 subjects from the cohort was genotyped for the following SNPs in ADAM33: F+1, Q-1, S_1, S_2, T_1, T_2, V_4, and ST+5. Differences in prevalence of SNPs were analyzed with {chi}2 tests. Linear mixed effects models were used to analyze FEV1 decline according to genotype. Measurements and Main Results: In the whole population, mean adjusted decline was 18.7 and 12.7 ml/year in females and males, respectively. Individuals homozygous for minor alleles of SNPs S_2 and Q-1 and heterozygous for SNP S_1 had a significantly accelerated decline in FEV1 of, respectively, 4.9, 9.6, and 3.6 ml/year compared with wild type. We found a significantly higher prevalence of SNPs F+1, S_1, S_2, and T_2 in subjects with COPD. Conclusions: We demonstrated that SNPs in ADAM33 are associated with accelerated lung function decline in the general population. These SNPs are also risk factors for COPD.

Key Words: ADAM33 • chronic obstructive pulmonary disease • FEV1 • genetics • single nucleotide polymorphism




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