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Computed Tomography in the Evaluation of Cystic Fibrosis Lung Disease

Department of Radiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati; Columbus Children's Hospital, The Children's Radiological Institute, Columbus, Ohio; Department of Pediatric Pulmonology, Erasmus MC–Sophia, Rotterdam, The Netherlands; Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada; Department of Radiology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles; Division of Pediatric Pulmonology, Packard Children's Hospital at Stanford, Palo Alto, California; State University of New York Upstate Medical University, Syracuse, New York; University of Wisconsin, Madison, Wisconsin; and Children's Hospital of Denver, Denver, Colorado

Correspondence and requests for reprints should be addressed to Alan S. Brody, M.D., Professor of Radiology and Pediatrics, Department of Radiology, MLC-5031, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229-3039. E-mail: alan.brody{at}cchmc.org

ABSTRACT

The first report of computed tomography (CT) scanning to monitor cystic fibrosis (CF)–related lung disease was published in 1986. Further publications followed, but in general there was little interest in this technique until recently. Two factors in particular have led to this increased interest. First is an increasing realization that pulmonary function tests, long the mainstay of CF evaluation, often underestimate the presence and severity of mild and moderate lung disease. Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF.

Key Words: computed tomography X-ray • cystic fibrosis • radiation effects • research design

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