help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on November 19, 2004, doi:10.1164/rccm.200409-1286OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow All Versions of this Article:
200409-1286OCv1
200409-1286OCv2
171/6/563    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Choudhry, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Choudhry, S.
American Journal of Respiratory and Critical Care Medicine Vol 171. pp. 563-570, (2005)
© 2005 American Thoracic Society
doi: 10.1164/rccm.200409-1286OC

Original Article

Pharmacogenetic Differences in Response to Albuterol between Puerto Ricans and Mexicans with Asthma

Shweta Choudhry, Ngim Ung, Pedro C. Avila, Elad Ziv, Sylvette Nazario, Jesus Casal, Alfonso Torres, Jennifer D. Gorman, Keyan Salari, Jose R. Rodriguez-Santana, Monica Toscano, Jody Senter Sylvia, MariaElena Alioto, Richard A. Castro, Michael Salazar, Ivan Gomez, Joanne K. Fagan, Jorge Salas, Suzanne Clark, Craig Lilly, Henry Matallana, Moises Selman, Rocio Chapela, Dean Sheppard, Scott T. Weiss, Jean G. Ford, Homer A. Boushey, Jeffrey M. Drazen, William Rodriguez-Cintron, Edwin K. Silverman and Esteban González Burchard on behalf of the Genetics of Asthma in Latino Americans (GALA) Study

University of California, San Francisco; Lung Biology Center, San Francisco General Hospital, San Francisco, California; San Juan Veterans Administration Medical Center, University of Puerto Rico School of Medicine; Pediatric Pulmonary Program of San Juan, San Juan, Puerto Rico; Brigham and Women's Hospital, Boston, Massachusetts; The Harlem Lung Center, Harlem Hospital and Columbia University, New York, New York; and Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

Correspondence and requests for reprints should be addressed to: Esteban González Burchard, M.D., University of California, San Francisco, San Francisco, CA 94143-0833. E-mail: eburch{at}itsa.ucsf.edu

Background: In the United States, Puerto Ricans and Mexicans have the highest and lowest asthma prevalence, morbidity, and mortality, respectively. Ethnic-specific differences in the response to drug treatment may contribute to differences in disease outcomes. Genetic variants at the ß2-adrenergic receptor (ß2AR) may modify asthma severity and albuterol responsiveness. We tested the association of ß2AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma. Methods: We used both family-based and cross-sectional tests of association with 8 ß2AR single nucleotide polymorphisms in 684 Puerto Rican and Mexican families. Regression analyses were used to determine the interaction between genotype, asthma severity, and bronchodilator drug responsiveness. Results: Among Puerto Ricans with asthma, the arginine (Arg) 16 allele was associated with greater bronchodilator response using both family-based and cross-sectional tests (p = 0.00001–0.01). We found a strong interaction of baseline FEV1 with the Arg16Glycine (Gly) polymorphism in predicting bronchodilator response. Among Puerto Ricans with asthma with baseline FEV1 < 80% of predicted, but not in those with FEV1 > 80%, there was a very strong association between the Arg16 genotype and greater bronchodilator responsiveness. No association was observed between Arg16Gly genotypes and drug responsiveness among Mexicans with asthma. Conclusions: Ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma. These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and drug responsiveness.

Key Words: asthma genetics • ß2-adrenergic receptor gene • Latinos • pharmacogenetic




This article has been cited by other articles:


Home page
 ChestHome page
K. Blake, R. Madabushi, H. Derendorf, and J. Lima
Population Pharmacodynamic Model of Bronchodilator Response to Inhaled Albuterol in Children and Adults With Asthma
Chest, November 1, 2008; 134(5): 981 - 989.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
M. C. Aldrich, S. Selvin, H. M. Hansen, L. F. Barcellos, M. R. Wrensch, J. D. Sison, C. P. Quesenberry, R. A. Kittles, G. Silva, P. A. Buffler, et al.
Comparison of Statistical Methods for Estimating Genetic Admixture in a Lung Cancer Study of African Americans and Latinos
Am. J. Epidemiol., November 1, 2008; 168(9): 1035 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 Social Studies of ScienceHome page
D. Fullwiley
The Biologistical Construction of Race: `Admixture' Technology and the New Genetic Medicine
Social Studies of Science, October 1, 2008; 38(5): 695 - 735.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Galanter, S. Choudhry, C. Eng, S. Nazario, J. R. Rodriguez-Santana, J. Casal, A. Torres-Palacios, J. Salas, R. Chapela, H. G. Watson, et al.
ORMDL3 Gene Is Associated with Asthma in Three Ethnically Diverse Populations
Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1194 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. Hizawa, H. Makita, Y. Nasuhara, T. Betsuyaku, Y. Itoh, K. Nagai, M. Hasegawa, and M. Nishimura
{beta}2-Adrenergic Receptor Genetic Polymorphisms and Short-term Bronchodilator Responses in Patients With COPD
Chest, November 1, 2007; 132(5): 1485 - 1492.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. B. Weiss
Eliminating Asthma Disparities: A National Workshop To Set a Working Agenda
Chest, November 1, 2007; 132(5_suppl): 753S - 756S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. V. Scirica and J. C. Celedon
Genetics of Asthma: Potential Implications for Reducing Asthma Disparities
Chest, November 1, 2007; 132(5_suppl): 770S - 781S.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. Choudhry, M. A. Seibold, L. N. Borrell, H. Tang, D. Serebrisky, R. Chapela, J. R. Rodriguez-Santana, P. C. Avila, E. Ziv, W. Rodriguez-Cintron, et al.
Dissecting Complex Diseases in Complex Populations: Asthma in Latino Americans
Proceedings of the ATS, July 1, 2007; 4(3): 226 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
R. B. Penn, V. E. Ortega, and E. R. Bleecker
A Roadmap to functional genomics
Physiol Genomics, June 19, 2007; 30(1): 82 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Panebra, M. R. Schwarb, C. B. Glinka, and S. B. Liggett
Allele-Specific Binding of Airway Nuclear Extracts to Polymorphic beta2-Adrenergic Receptor 5' Sequence
Am. J. Respir. Cell Mol. Biol., June 1, 2007; 36(6): 654 - 660.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. T. Cohen, G. J. Canino, H. R. Bird, S. Shen, B. A. Rosner, and J. C. Celedon
Area of Residence, Birthplace, and Asthma in Puerto Rican Children
Chest, May 1, 2007; 131(5): 1331 - 1338.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Choudhry, E. G. Burchard, L. N. Borrell, H. Tang, I. Gomez, M. Naqvi, S. Nazario, A. Torres, J. Casal, J. C. Martinez-Cruzado, et al.
Ancestry-Environment Interactions and Asthma Risk among Puerto Ricans
Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1088 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Public HealthHome page
D. Rose, D. M. Mannino, and B. P. Leaderer
Asthma Prevalence Among US Adults, 1998-2000: Role of Puerto Rican Ethnicity and Behavioral and Geographic Factors
Am J Public Health, May 1, 2006; 96(5): 880 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. Wenzel and R. Covar
Update in asthma 2005.
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 698 - 706.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. E. Wechsler, E. Lehman, S. C. Lazarus, R. F. Lemanske Jr., H. A. Boushey, A. Deykin, J. V. Fahy, C. A. Sorkness, V. M. Chinchilli, T. J. Craig, et al.
beta-Adrenergic Receptor Polymorphisms and Response to Salmeterol
Am. J. Respir. Crit. Care Med., March 1, 2006; 173(5): 519 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. Hunninghake, S. T. Weiss, and J. C. Celedon
Asthma in Hispanics
Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 143 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Public HealthHome page
E. Gonzalez Burchard, L. N. Borrell, S. Choudhry, M. Naqvi, H.-J. Tsai, J. R. Rodriguez-Santana, R. Chapela, S. D. Rogers, R. Mei, W. Rodriguez-Cintron, et al.
Latino Populations: A Unique Opportunity for the Study of Race, Genetics, and Social Environment in Epidemiological Research
Am J Public Health, December 1, 2005; 95(12): 2161 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
K. C. Barnes
Genetic Determinants and Ethnic Disparities in Sepsis-associated Acute Lung Injury
Proceedings of the ATS, October 1, 2005; 2(3): 195 - 201.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. R. Taylor, M. J. Epton, M. A. Kennedy, A. D. Smith, S. Iles, A. L. Miller, M. D. Littlejohn, J. O. Cowan, T. Hewitt, M. P. Swanney, et al.
Bronchodilator Response in Relation to {beta}2-Adrenoceptor Haplotype in Patients with Asthma
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 700 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. E. Wechsler and E. Israel
How Pharmacogenomics Will Play a Role in the Management of Asthma
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 12 - 18.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. P. Hall
Pharmacogenetics and Ethnicity: More Complexities of Personalized Prescribing
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 535 - 536.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS State of the Art 2009