help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NIELSEN, K. G.
Right arrow Articles by BISGAARD, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NIELSEN, K. G.
Right arrow Articles by BISGAARD, H.

Am. J. Respir. Crit. Care Med., Volume 162, Number 4, October 2000, 1500-1506

The Effect of Inhaled Budesonide on Symptoms, Lung Function, and Cold Air and Methacholine Responsiveness in 2- to 5-year-old Asthmatic Children

KIM GJERUM NIELSEN and HANS BISGAARD

Department of Pediatrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

We hypothesized that measurement of lung function (LF) and bronchial hyperresponsiveness (BHR) could serve as supplemental tools in evaluating the efficacy of treatment with inhaled corticosteroids in asthmatic children aged 2 to 5 yr. We studied 38 children (mean age: 53 mo; range: 35 to 71 mo) with moderately severe asthma in a single-center, randomized, double-blind, parallel-group, placebo-controlled study involving 8 wk of treatment. Budesonide (BUD) 400 µg twice daily was administered via a pressurized metered-dose inhaler and metal spacer device. Symptom scores (SSc) and use of short-acting beta 2-agonist were monitored with diary cards. LF in awake children was measured as the specific airway resistance (sRaw), using whole-body plethysmography; as resistance by the interrupter technique (Rint); and as resistance and reactance at 5 Hz (Rrs5, Xrs5) by the impulse oscillation technique. Cold air challenge (CACh) and methacholine challenge (MCh) were used to assess BHR. Children in the BUD group experienced significantly fewer night- and daytime symptoms (p < 0.05) and more symptom-free days (p < 0.05), but not nights (p = 0.07), than children in the placebo group. Daytime (p < 0.05) but not nighttime (p = 0.09) use of rescue medication and asthma exacerbation rates (3.7 versus 9.3 exacerbations/yr) (p = 0.006) were both in favor of BUD. LF measured with the Rint technique, Rrs5, and Xrs5 were significantly improved by BUD. BHR as measured by CACh improved significantly with BUD, whereas no improvement was found on MCh. In conclusion, inhaled BUD at a total dose of 800 µg daily significantly improved SSc, asthma exacerbation rates, lung function, and BHR as assessed by CACh in asthmatic children aged 2 to 5 yr.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
E. D. Bateman, S. S. Hurd, P. J. Barnes, J. Bousquet, J. M. Drazen, M. FitzGerald, P. Gibson, K. Ohta, P. O'Byrne, S. E. Pedersen, et al.
Global strategy for asthma management and prevention: GINA executive summary
Eur. Respir. J., January 1, 2008; 31(1): 143 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Beydon, S. D. Davis, E. Lombardi, J. L. Allen, H. G. M. Arets, P. Aurora, H. Bisgaard, G. M. Davis, F. M. Ducharme, H. Eigen, et al.
An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1304 - 1345.
[Full Text] [PDF]

Home page
 NEJMHome page
D. Kohler, P. Haidl, D. Dellweg, L. Bont, J. L.L. Kimpen, M. J.J. Ermers, E. Baraldi, M. Filippone, T. Guilbert, F. D. Martinez, et al.
Inhaled corticosteroids and children.
N. Engl. J. Med., August 10, 2006; 355(6): 624 - 624.
[Full Text] [PDF]

Home page
 AAP Grand RoundsHome page
C. Randolph
Efficacy of Long-Term Inhaled Corticosteroids for Asthma in High-Risk Preschool Children
AAP Grand Rounds, July 1, 2006; 16(1): 85 - 86.
[Full Text] [PDF]

Home page
 NEJMHome page
T. W. Guilbert, W. J. Morgan, R. S. Zeiger, D. T. Mauger, S. J. Boehmer, S. J. Szefler, L. B. Bacharier, R. F. Lemanske Jr., R. C. Strunk, D. B. Allen, et al.
Long-term inhaled corticosteroids in preschool children at high risk for asthma.
N. Engl. J. Med., May 11, 2006; 354(19): 1985 - 1997.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
H. Bisgaard, M. N. Hermansen, L. Loland, L. B. Halkjaer, and F. Buchvald
Intermittent inhaled corticosteroids in infants with episodic wheezing.
N. Engl. J. Med., May 11, 2006; 354(19): 1998 - 2005.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M R Thomas, G F Rafferty, R Blowes, J L Peacock, N Marlow, S Calvert, A Milner, and A Greenough
Plethysmograph and interrupter resistance measurements in prematurely born young children
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F193 - F196.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
Diagnosis of asthma
Can. Med. Assoc. J., September 13, 2005; 173(6_suppl): S15 - S19.
[Full Text] [PDF]

Home page
 ChestHome page
H. Bisgaard and K. G. Nielsen
Plethysmographic Measurements of Specific Airway Resistance in Young Children
Chest, July 1, 2005; 128(1): 355 - 362.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. Teper, C. D. Kofman, G. A. Szulman, S. M. Vidaurreta, and A. F. Maffey
Fluticasone Improves Pulmonary Function in Children under 2 Years Old with Risk Factors for Asthma
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 587 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. A. Straub, A. Moeller, S. Minocchieri, J. Hamacher, F. H. Sennhauser, G. L. Hall, and J. H. Wildhaber
The effect of montelukast on lung function and exhaled nitric oxide in infants with early childhood asthma
Eur. Respir. J., February 1, 2005; 25(2): 289 - 294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. G. Nielsen and H. Bisgaard
Hyperventilation with Cold versus Dry Air in 2- to 5-Year-Old Children with Asthma
Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 238 - 241.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Skloot, M. Goldman, D. Fischler, C. Goldman, C. Schechter, S. Levin, and A. Teirstein
Respiratory Symptoms and Physiologic Assessment of Ironworkers at the World Trade Center Disaster Site
Chest, April 1, 2004; 125(4): 1248 - 1255.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
H. Bisgaard, D. Allen, J. Milanowski, I. Kalev, L. Willits, and P. Davies
Twelve-Month Safety and Efficacy of Inhaled Fluticasone Propionate in Children Aged 1 to 3 Years With Recurrent Wheezing
Pediatrics, February 1, 2004; 113(2): e87 - 94.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Saglani, D N R Payne, A G Nicholson, M Scallan, E Haxby, and A Bush
The safety and quality of endobronchial biopsy in children under five years old
Thorax, December 1, 2003; 58(12): 1053 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
H. O. Koskela, L. Hyvarinen, J. D. Brannan, H.-K. Chan, and S. D. Anderson
Sensitivity and Validity of Three Bronchial Provocation Tests To Demonstrate the Effect of Inhaled Corticosteroids in Asthma
Chest, October 1, 2003; 124(4): 1341 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. S. Pao and S. A. McKenzie
Randomized Controlled Trial of Fluticasone in Preschool Children with Intermittent Wheeze
Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 945 - 949.
[Abstract] [Full Text]

Home page
 ChestHome page
H. Bisgaard, M. J. Price, C. Maden, and N. A. Olsen
Cost-Effectiveness of Fluticasone Propionate Administered Via Metered-Dose Inhaler Plus BabyhalerTM Spacer in the Treatment of Asthma in Preschool-Aged Children
Chest, December 1, 2001; 120(6): 1835 - 1842.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1581 - 1594.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. G. NIELSEN and H. BISGAARD
Discriminative Capacity of Bronchodilator Response Measured with Three Different Lung Function Techniques in Asthmatic and Healthy Children Aged 2 to 5 Years
Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 554 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. G. NIELSEN and H. BISGAARD
Bronchodilation and Bronchoprotection in Asthmatic Preschool Children from Formoterol Administered by Mechanically Actuated Dry-powder Inhaler and Spacer
Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 256 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. W. Cockcroft
How Best to Measure Airway Responsiveness
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1514 - 1515.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Bisgaard
Persistent Wheezing in Very Young Preschool Children Reflects Lower Respiratory Inflammation
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1290 - 1291.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. S. Pao, S. A. McKenzie, H. Bisgaard, and K. G. Nielsen
INHALED CORTICOSTEROIDS FOR PERSISTENT WHEEZE IN PRESCHOOL CHILDREN
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1278 - 1278.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  ATS State of the Art 2009