Am. J. Respir. Crit. Care Med., Volume 162, Number 1, July 2000, 328-330

Treatment of Nosocomial Pneumonia and Tracheobronchitis Caused by Multidrug-Resistant Pseudomonas aeruginosa with Aerosolized Colistin

DAVIDSON H. HAMER

Department of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts

Gram-negative bacilli including multidrug-resistant (MDR) Pseudomonas aeruginosa are responsible for a significant proportion of episodes of nosocomial pneumonia. Since the development of new antibiotics with activity against gram-negative organisms has not kept pace with the increase in prevalence of MDR pathogens, there has been renewed interest in antimicrobial agents that had previously been used but had been abandoned because of toxic side effects. This report describes three patients with nosocomial pneumonia or tracheobronchitis due to multiresistant strains of P. aeruginosa for whom aerosolized colistin proved beneficial as supplemental therapy. Aerosolized colistin merits further consideration as a therapeutic intervention for patients with pulmonary infections due to MDR P. aeruginosa.

This article has been cited by other articles:

				H. Aly, M. Badawy, A. El-Kholy, R. Nabil, and A. Mohamed Randomized, Controlled Trial on Tracheal Colonization of Ventilated Infants: Can Gravity Prevent Ventilator-Associated Pneumonia? Pediatrics, October 1, 2008; 122(4): 770 - 774. [Abstract] [Full Text] [PDF]

				S. J. Wallace, J. Li, Craig. R. Rayner, K. Coulthard, and R. L. Nation Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients Antimicrob. Agents Chemother., September 1, 2008; 52(9): 3047 - 3051. [Abstract] [Full Text] [PDF]

				D. Landman, C. Georgescu, D. A. Martin, and J. Quale Polymyxins Revisited Clin. Microbiol. Rev., July 1, 2008; 21(3): 449 - 465. [Abstract] [Full Text] [PDF]

				A. Y. Peleg, H. Seifert, and D. L. Paterson Acinetobacter baumannii: Emergence of a Successful Pathogen Clin. Microbiol. Rev., July 1, 2008; 21(3): 538 - 582. [Abstract] [Full Text] [PDF]

				E. Ioannidou, I. I. Siempos, and M. E. Falagas Administration of antimicrobials via the respiratory tract for the treatment of patients with nosocomial pneumonia: a meta-analysis J. Antimicrob. Chemother., December 1, 2007; 60(6): 1216 - 1226. [Abstract] [Full Text] [PDF]

				R. Y. Hachem, R. F. Chemaly, C. A. Ahmar, Y. Jiang, M. R. Boktour, G. A. Rjaili, G. P. Bodey, and I. I. Raad Colistin Is Effective in Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa in Cancer Patients Antimicrob. Agents Chemother., June 1, 2007; 51(6): 1905 - 1911. [Abstract] [Full Text] [PDF]

				M. E. Falagas, P. K. Koletsi, and I. A. Bliziotis The diversity of definitions of multidrug-resistant (MDR) and pandrug-resistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa. J. Med. Microbiol., December 1, 2006; 55(Pt 12): 1619 - 1629. [Abstract] [Full Text] [PDF]

				M. B. Shirk, K. R. Donahue, and J. Shirvani Unlabeled uses of nebulized medications. Am. J. Health Syst. Pharm., September 15, 2006; 63(18): 1704 - 1716. [Abstract] [Full Text] [PDF]

				H. A Hakeam and A. M Almohaizeie Hypotension Following Treatment with Aerosolized Colistin in a Patient with Multidrug-Resistant Pseudomonas aeruginosa Ann. Pharmacother., September 1, 2006; 40(9): 1677 - 1680. [Abstract] [Full Text] [PDF]

				M. E. Falagas, S. K. Kasiakou, S. Tsiodras, and A. Michalopoulos The use of intravenous and aerosolized polymyxins for the treatment of infections in critically ill patients: a review of the recent literature. Clin. Med. Res., June 1, 2006; 4(2): 138 - 146. [Abstract] [Full Text] [PDF]

				V. H. Tam, A. N. Schilling, G. Vo, S. Kabbara, A. L. Kwa, N. P. Wiederhold, and R. E. Lewis Pharmacodynamics of Polymyxin B against Pseudomonas aeruginosa Antimicrob. Agents Chemother., September 1, 2005; 49(9): 3624 - 3630. [Abstract] [Full Text] [PDF]

				Guidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and Healthcare-associated Pneumonia Am. J. Respir. Crit. Care Med., February 15, 2005; 171(4): 388 - 416. [Full Text] [PDF]

				D. Berlana, J. M. Llop, E. Fort, M. B. Badia, and R. Jodar Use of colistin in the treatment of multiple-drug-resistant gram-negative infections Am. J. Health Syst. Pharm., January 1, 2005; 62(1): 39 - 47. [Abstract] [Full Text] [PDF]

				R. M. Mehta and M. S. Niederman Nosocomial Pneumonia in the Intensive Care Unit: Controversies and Dilemmas J Intensive Care Med, July 1, 2003; 18(4): 175 - 188. [Abstract] [PDF]

				H. Giamarellou Prescribing guidelines for severe Pseudomonas infections J. Antimicrob. Chemother., February 1, 2002; 49(2): 229 - 233. [Full Text] [PDF]

				M. J. TOBIN Tuberculosis, Lung Infections, and Interstitial Lung Disease in AJRCCM 2000 Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1774 - 1788. [Full Text] [PDF]