help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by VINCENT, J.-L.
Right arrow Articles by PREISER, J.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by VINCENT, J.-L.
Right arrow Articles by PREISER, J.-C.

Am. J. Respir. Crit. Care Med., Volume 161, Number 6, June 2000, 1781-1785

Effects of Nitric Oxide in Septic Shock

JEAN-LOUIS VINCENT, HAIBO ZHANG, CSABA SZABO, and JEAN-CHARLES PREISER

Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium; Division of Respiratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Division of Critical Care, Children's Hospital Medical Center, Cincinatti, Ohio

Nitric oxide (NO) is believed to play a key role in the pathogenesis of septic shock, although many aspects of NO's involvement remain poorly defined. Recent years have seen advances in our understanding of the production and effects of NO, but much of the work has been done in animal models and may not be directly relevant to the clinical situation. Differences between species and models can account for many of the apparently conflicting results obtained. Nevertheless, NO-directed strategies have been developed and tested clinically. However, NO can have both beneficial and detrimental effects on many organ systems in sepsis and attempts to nonselectively block all its actions may therefore not yield positive results on outcome. Further exploration and precision of the role of NO and development of techniques to assess the NO balance in individual patients is necessary before further progress can be made in this field.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Sayk, A. Vietheer, B. Schaaf, P. Wellhoener, G. Weitz, H. Lehnert, and C. Dodt
Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R891 - R898.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. I. Hashemy and A. Holmgren
Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues
J. Biol. Chem., August 8, 2008; 283(32): 21890 - 21898.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
D.-Z. Hsu, S.-P. Chien, Y.-H. Li, Y.-C. Chuang, Y.-C. Chang, and M.-Y. Liu
Sesame Oil Attenuates Hepatic Lipid Peroxidation by Inhibiting Nitric Oxide and Superoxide Anion Generation in Septic Rats
JPEN J Parenter Enteral Nutr, March 1, 2008; 32(2): 154 - 159.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. Cayla, M. Todiras, R. Iliescu, V. V. Saul, V. Gross, B. Pilz, G. Chai, V. F. Merino, J. B. Pesquero, O. C. Baltatu, et al.
Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension
FASEB J, June 1, 2007; 21(8): 1689 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. E. Broderick, J. Feala, A. McCulloch, G. Paternostro, V. S. Sharma, R. B. Pilz, and G. R. Boss
The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis
FASEB J, September 1, 2006; 20(11): 1865 - 1873.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. Wang, W. Li, J. Li, B. Rendon-Mitchell, M. Ochani, M. Ashok, L. Yang, H. Yang, K. J. Tracey, P. Wang, et al.
The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica sinensis, Protects Mice against Lethal Endotoxemia and Sepsis
J. Nutr., February 1, 2006; 136(2): 360 - 365.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. S. Dhillon, K. Mahadevan, V. Bandi, Z. Zheng, C. W. Smith, and R. E. Rumbaut
Neutrophils, Nitric Oxide, and Microvascular Permeability in Severe Sepsis
Chest, September 1, 2005; 128(3): 1706 - 1712.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
B. Hauser, H. Bracht, M. Matejovic, P. Radermacher, and B. Venkatesh
Nitric Oxide Synthase Inhibition in Sepsis? Lessons Learned from Large-Animal Studies
Anesth. Analg., August 1, 2005; 101(2): 488 - 498.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. E. Broderick, V. Singh, S. Zhuang, A. Kambo, J. C. Chen, V. S. Sharma, R. B. Pilz, and G. R. Boss
Nitric Oxide Scavenging by the Cobalamin Precursor Cobinamide
J. Biol. Chem., March 11, 2005; 280(10): 8678 - 8685.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J.-J. Boffa and W. J. Arendshorst
Maintenance of Renal Vascular Reactivity Contributes to Acute Renal Failure during Endotoxemic Shock
J. Am. Soc. Nephrol., January 1, 2005; 16(1): 117 - 124.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Falcone, C. Perrotta, C. De Palma, A. Pisconti, C. Sciorati, A. Capobianco, P. Rovere-Querini, A. A. Manfredi, and E. Clementi
Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3',5'-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells
J. Immunol., October 1, 2004; 173(7): 4452 - 4463.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Kadoi and F. Goto
Selective Inducible Nitric Oxide Inhibition Can Restore Hemodynamics, but Does Not Improve Neurological Dysfunction in Experimentally-Induced Septic Shock in Rats
Anesth. Analg., July 1, 2004; 99(1): 212 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. C. Rudkowski, E. Barreiro, R. Harfouche, P. Goldberg, O. Kishta, P. D'Orleans-Juste, J. Labonte, O. Lesur, and S. N. A. Hussain
Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L793 - L800.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Hemmrich, C. V. Suschek, G. Lerzynski, and V. Kolb-Bachofen
iNOS activity is essential for endothelial stress gene expression protecting against oxidative damage
J Appl Physiol, November 1, 2003; 95(5): 1937 - 1946.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. Almog
Statins, Inflammation, and Sepsis: Hypothesis
Chest, August 1, 2003; 124(2): 740 - 743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-J. Rouby
The Nose, Nitric Oxide, and Paranasal Sinuses: The Outpost of Pulmonary Antiinfectious Defenses?
Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 265 - 266.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Keh, T. Boehnke, S. Weber-Cartens, C. Schulz, O. Ahlers, S. Bercker, H.-D. Volk, W.-D. Doecke, K. J. Falke, and H. Gerlach
Immunologic and Hemodynamic Effects of "Low-Dose" Hydrocortisone in Septic Shock: A Double-Blind, Randomized, Placebo-controlled, Crossover Study
Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 512 - 520.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. I. COHEN, A.-M. HASSELL, K. MARZOUK, C. MARINI, S. F. LIU, and S. M. SCHARF
Renal Effects of Nitric Oxide in Endotoxemia
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1890 - 1895.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2000
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1347 - 1361.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Creteur, Q. Sun, O. Abid, D. De Backer, P. Van Der Linden, and J.-L. Vincent
Normovolemic hemodilution improves oxygen extraction capabilities in endotoxic shock
J Appl Physiol, October 1, 2001; 91(4): 1701 - 1707.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. D Higgins and M. Keszler
Perinatal vascular development
Cardiovasc Res, July 1, 2001; 51(1): 7 - 8.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. T. Stitt and A. B. DuBois
The lung diffusing capacity for nitric oxide in rats is increased during endotoxemia
J Appl Physiol, March 1, 2001; 90(3): 1049 - 1056.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  ATS Clinical Skills Tests