Am. J. Respir. Crit. Care Med., Volume 157, Number 5, May 1998, 1578-1585

Effect of Lung Volume Reduction Surgery on Diaphragm Strength

GERARD CRINER, FRANCIS C. CORDOVA, VADIM LEYENSON, BRUCE ROY, JOHN TRAVALINE, SHRIVAS SUDARSHAN, GERALD O'BRIEN, ANNE MARIE KUZMA, and SATOSHI FURUKAWA

Divisions of Pulmonary and Critical Care Medicine, Department of Medicine and Cardiothoracic Surgery, and Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania

Since lung volume reduction surgery (LVRS) reduces end-expiratory lung volume, we hypothesized that it may improve diaphragm strength. We evaluated 37 patients for pulmonary rehabilitation and LVRS. Before and 8 wk after pulmonary rehabilitation, 24 patients had spirometry, lung volumes, diffusion capacity, incremental symptom limited maximum exercise test, 6-min walk test, maximal static inspiratory and expiratory mouth pressures, and transdiaphragmatic pressures during maximum static inspiratory efforts and bilateral supramaximal electrophrenic twitch stimulation measured. Twenty patients (including 7 patients who crossed over after completing pulmonary rehabilitation) had baseline measurements postrehabilitation, and 3 mo post-LVRS. Patients were 58 ± 8 yr of age, with severe COPD and hyperinflation (FEV₁, 0.69 ± 0.21 L; RV, 4.7 ± 1.4 L). Nineteen patients had bilateral LVRS performed via median sternotomy and stapling, and 1 patient had unilateral LVRS via thorascopy with stapling. After rehabilitation, spirometry and DL_CO/ VA were not different, and lung volumes showed a slight worsening in hyperinflation. Gas exchange, 6-min walk distance, maximum oxygen uptake ( O₂max), and breathing pattern during maximum exercise did not change after rehabilitation, but total exercise time was significantly longer. Inspiratory muscle strength (PI_max, Pdi_{max combined}, Pdi_{max sniff}, Pdi_max, Pdi_twitch), was unchanged after rehabilitation. In contrast, after LVRS, FVC increased 21%, FEV₁ increased 34%, TLC decreased 13%, FRC decreased 23%, and FRC_{trapped gas} and RV decreased by 57 and 28%, respectively. PCO₂ was lower (44 ± 6 versus 48 ± 6 mm Hg, p < 0.003) and 6-min walk distance increased (343 ± 79 versus 250 ± 89 m, p < 0.001), as did total exercise time during maximum exercise (9.2 ± 1.9 versus 6.9 ± 2.7 min, p < 0.01). Minute ventilation (29 ± 8 versus 21 ± 6 L /min, p < 0.001) and tidal volume (1.0 ± 0.33 versus 0.84 ± 0.25 L, p < 0.001) during maximum exercise increased whereas respiratory rate was lower (28 ± 6 versus 32 ± 7 breaths/min, p < 0.02). Measurements of respiratory muscle strength (PI_max, 74 ± 28 versus 50 ± 18 cm H₂O, p < 0.002; Pdi_{max combined}, 80 ± 25 versus 56 ± 29 cm H₂O, p < 0.01; Pdi_{max sniff}, 71 ± 7 versus 46 ± 27 cm H₂O, p < 0.01; Pdi_twitch, 15 ± 5 versus 7 ± 5 cm H₂O, p < 0.01) were all greater post-LVRS. Inspiratory muscle workload as measured by Pdi TTI was lower following LVRS (0.07 ± 0.02 versus 0.09 ± 0.03, p < 0.03). On multiple regression analysis, increases in PI_max correlated significantly with decreases in RV and FRC_{trapped gas} after LVRS (r = 0.67, p < 0.03). We conclude that LVRS significantly improves diaphragm strength that is associated with a reduction in lung volumes and an improvement in exercise performance. Future studies are needed to determine the relationship and stability of these changes over time.

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