help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MATUTE-BELLO, G.
Right arrow Articles by MARTIN, T. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MATUTE-BELLO, G.
Right arrow Articles by MARTIN, T. R.

Am. J. Respir. Crit. Care Med., Volume 156, Number 6, December 1997, 1969-1977

Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome

GUSTAVO MATUTE-BELLO, W. CONRAD LILES, FRANK RADELLA II, KENNETH P. STEINBERG, JOHN T. RUZINSKI, MECHTHILD JONAS, EMIL Y. CHI, LEONARD D. HUDSON, and THOMAS R. MARTIN

Section of Pulmonary and Critical Care Medicine, Harborview Medical Center; the Medical Research Service, Seattle VA Medical Center; the Divisions of Pulmonary and Critical Care Medicine and Infectious Diseases, Departments of Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington

Little is known about neutrophil (PMN) apoptosis in the acute respiratory distress syndrome (ARDS). We used morphologic criteria to count apoptotic PMN in bronchoalveolar lavage fluid (BAL) of 35 patients on Days 1, 3, 7, 14, and 21 of ARDS and 13 patients on Days 1 and 3 of risk for ARDS. We found that the proportion of apoptotic PMN in BAL was low throughout the course of ARDS. There was no significant difference between the percentage of apoptotic PMN in patients at risk and patients with established ARDS or between patients who lived (2.4%) and patients who died (1.8%). When normal human PMN were incubated in ARDS BAL, a significantly lower proportion became apoptotic (50 ± 4%), as compared with PMN incubated in lavage fluid from normal volunteers (76 ± 7%, p < 0.05). This antiapoptotic effect of ARDS BAL was blocked by immunodepleting BAL of G-CSF and GM-CSF. We conclude that the proportion of apoptotic PMN recovered from the lungs of patients with ARDS is low throughout the course of ARDS. Furthermore, BAL from patients with ARDS prolongs survival of normal human PMN in vitro, and this effect is partially mediated by G-CSF and GM-CSF. Matute-Bello G, Liles WC, Radella F, II, Steinberg KP, Ruzinski JT, Jonas M, Chi EY, Hudson LD, Martin TR. Neutrophil apoptosis in the acute respiratory distress syndrome.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. A. Bem, J. B. M. van Woensel, A. P. Bos, A. Koski, A. W. Farnand, J. B. Domachowske, H. F. Rosenberg, T. R. Martin, and G. Matute-Bello
Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection
Am J Physiol Lung Cell Mol Physiol, January 1, 2009; 296(1): L46 - L56.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. El Kebir, L. Jozsef, and J. G. Filep
Opposing regulation of neutrophil apoptosis through the formyl peptide receptor-like 1/lipoxin A4 receptor: implications for resolution of inflammation
J. Leukoc. Biol., September 1, 2008; 84(3): 600 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. El Kebir, L. Jozsef, W. Pan, and J. G. Filep
Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation
Circ. Res., August 15, 2008; 103(4): 352 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. J. Janssen, K. A. McPhillips, M. G. Dickinson, D. J. Linderman, K. Morimoto, Y. Q. Xiao, K. M. Oldham, R. W. Vandivier, P. M. Henson, and S. J. Gardai
Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRP{alpha}
Am. J. Respir. Crit. Care Med., July 15, 2008; 178(2): 158 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Z. Wang, D. Beach, L. Su, R. Zhai, and D. C. Christiani
A Genome-Wide Expression Analysis in Blood Identifies Pre-Elafin as a Biomarker in ARDS
Am. J. Respir. Cell Mol. Biol., June 1, 2008; 38(6): 724 - 732.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. M. Marriott, L. E. Jackson, T. S. Wilkinson, A. J. Simpson, T. J. Mitchell, D. J. Buttle, S. S. Cross, P. G. Ince, P. G. Hellewell, M. K. B. Whyte, et al.
Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 887 - 895.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. S. Tang, M. Mura, R. Seth, and M. Liu
Acute lung injury and cell death: how many ways can cells die?
Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L632 - L641.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Wang, H. Rosen, D. K. Madtes, B. Shao, T. R. Martin, J. W. Heinecke, and X. Fu
Myeloperoxidase Inactivates TIMP-1 by Oxidizing Its N-terminal Cysteine Residue: AN OXIDATIVE MECHANISM FOR REGULATING PROTEOLYSIS DURING INFLAMMATION
J. Biol. Chem., November 2, 2007; 282(44): 31826 - 31834.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Fudala, A. Krupa, M. A. Matthay, T. C. Allen, and A. K. Kurdowska
Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L364 - L374.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. El Kebir, L. Jozsef, T. Khreiss, W. Pan, N. A. Petasis, C. N. Serhan, and J. G. Filep
Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation
J. Immunol., July 1, 2007; 179(1): 616 - 622.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Petty, V. Sueblinvong, C. C. Lenox, C. C. Jones, G. P. Cosgrove, C. D. Cool, P. R. Rai, K. K. Brown, D. J. Weiss, M. E. Poynter, et al.
Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury
J. Immunol., June 15, 2007; 178(12): 8148 - 8157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. B. Allen, T. Leclair, M. Cloutier, J. Thompson-Figueroa, and J. H. T. Bates
The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspiration
Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1580 - L1589.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. E. Kilpatrick, S. Sun, D. Mackie, F. Baik, H. Li, and H. M. Korchak
Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of {delta}-PKC and ERK1/2
J. Leukoc. Biol., December 1, 2006; 80(6): 1512 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Rytila, M. Plataki, F. Bucchieri, M. Uddin, G. Nong, V. L. Kinnula, and R. Djukanovic
Airway neutrophilia in COPD is not associated with increased neutrophil survival
Eur. Respir. J., December 1, 2006; 28(6): 1163 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. D. Coldren, J. A. Nick, K. R. Poch, M. D. Woolum, B. W. Fouty, J. M. O'Brien, M. P. Gruber, M. R. Zamora, D. Svetkauskaite, D. A. Richter, et al.
Functional and genomic changes induced by alveolar transmigration in human neutrophils
Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1267 - L1276.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C M McDougall and P J Helms
Neutrophil airway inflammation in childhood asthma
Thorax, September 1, 2006; 61(9): 739 - 741.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. M. Schnapp, S. Donohoe, J. Chen, D. A. Sunde, P. M. Kelly, J. Ruzinski, T. Martin, and D. R. Goodlett
Mining the Acute Respiratory Distress Syndrome Proteome: Identification of the Insulin-Like Growth Factor (IGF)/IGF-Binding Protein-3 Pathway in Acute Lung Injury
Am. J. Pathol., July 1, 2006; 169(1): 86 - 95.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. W. Vandivier, P. M. Henson, and I. S. Douglas
Burying the Dead: The Impact of Failed Apoptotic Cell Removal (Efferocytosis) on Chronic Inflammatory Lung Disease
Chest, June 1, 2006; 129(6): 1673 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. S. Cowburn, A. Sobolewski, B. J. Reed, J. Deighton, J. Murray, K. A. Cadwallader, J. R. Bradley, and E. R. Chilvers
Aminopeptidase N (CD13) Regulates Tumor Necrosis Factor-{alpha}-induced Apoptosis in Human Neutrophils
J. Biol. Chem., May 5, 2006; 281(18): 12458 - 12467.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
J. S. Steingrub
Adding up the zeros.
J Intensive Care Med, May 1, 2006; 21(3): 188 - 190.
[PDF]

Home page
 J. Immunol.Home page
I. Nagaoka, H. Tamura, and M. Hirata
An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7.
J. Immunol., March 1, 2006; 176(5): 3044 - 3052.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
D. E. Wesche-Soldato, J. L. Lomas-Neira, M. Perl, L. Jones, C.-S. Chung, and A. Ayala
The role and regulation of apoptosis in sepsis
Innate Immunity, December 1, 2005; 11(6): 375 - 382.
[Abstract] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. A. Matthay and G. A. Zimmerman
Acute Lung Injury and the Acute Respiratory Distress Syndrome: Four Decades of Inquiry into Pathogenesis and Rational Management
Am. J. Respir. Cell Mol. Biol., October 1, 2005; 33(4): 319 - 327.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. R. Martin, N. Hagimoto, M. Nakamura, and G. Matute-Bello
Apoptosis and Epithelial Injury in the Lungs
Proceedings of the ATS, October 1, 2005; 2(3): 214 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Karamlou, J. M. Schultz, C. Silliman, C. Sandquist, J. You, I. Shen, and R. M. Ungerleider
Using a Miniaturized Circuit and an Asanguineous Prime to Reduce Neutrophil-Mediated Organ Dysfunction Following Infant Cardiopulmonary Bypass
Ann. Thorac. Surg., July 1, 2005; 80(1): 6 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Allen, D. H. Dockrell, T. Pattery, D. G. Lee, P. Cornelis, P. G. Hellewell, and M. K. B. Whyte
Pyocyanin Production by Pseudomonas aeruginosa Induces Neutrophil Apoptosis and Impairs Neutrophil-Mediated Host Defenses In Vivo
J. Immunol., March 15, 2005; 174(6): 3643 - 3649.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A R L Medford, L J Keen, J L Bidwell, and A B Millar
Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome
Thorax, March 1, 2005; 60(3): 244 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Hu, X. Lin, Q. Du, E. J. Miller, P. Wang, and H. H. Simms
Regulation of polymorphonuclear leukocyte apoptosis: role of lung endothelium-epithelium bilayer transmigration
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L266 - L274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. E. Kilpatrick, S. Sun, and H. M. Korchak
Selective regulation by {delta}-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils
Am J Physiol Cell Physiol, September 1, 2004; 287(3): C633 - C642.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Asensi, E. Valle, A. Meana, J. Fierer, A. Celada, V. Alvarez, J. Paz, E. Coto, J. A. Carton, J. A. Maradona, et al.
In Vivo Interleukin-6 Protects Neutrophils from Apoptosis in Osteomyelitis
Infect. Immun., July 1, 2004; 72(7): 3823 - 3828.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.W.R. Pletz, M. Ioanas, A. de Roux, O. Burkhardt, and H. Lode
Reduced spontaneous apoptosis in peripheral blood neutrophils during exacerbation of COPD
Eur. Respir. J., April 1, 2004; 23(4): 532 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. C. Rudkowski, E. Barreiro, R. Harfouche, P. Goldberg, O. Kishta, P. D'Orleans-Juste, J. Labonte, O. Lesur, and S. N. A. Hussain
Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L793 - L800.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A P Watt, V Brown, J Courtney, M Kelly, L Garske, J S Elborn, and M Ennis
Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis
Thorax, March 1, 2004; 59(3): 231 - 236.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. J. Wiedermann, A. J. Mayr, N. C. Kaneider, D. Fuchs, N. J. Mutz, and W. Schobersberger
Alveolar Granulocyte Colony-Stimulating Factor and {alpha}-Chemokines in Relation to Serum Levels, Pulmonary Neutrophilia, and Severity of Lung Injury in ARDS
Chest, January 1, 2004; 125(1): 212 - 219.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Z. Hu and M. M. Sayeed
Suppression of mitochondria-dependent neutrophil apoptosis with thermal injury
Am J Physiol Cell Physiol, January 1, 2004; 286(1): C170 - C178.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Kotecha, R J Mildner, L R Prince, J R Vyas, A E Currie, R A Lawson, and M K B Whyte
The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants
Thorax, November 1, 2003; 58(11): 961 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. Y.L. Lam, T. H. Rainer, L. Y.S. Chan, G. M. Joynt, and Y.M. D. Lo
Time Course of Early and Late Changes in Plasma DNA in Trauma Patients
Clin. Chem., August 1, 2003; 49(8): 1286 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Murai, K. Nagai, H. Fujisawa, K. Hatanaka, M. Kawamura, and Y. Harada
Concurrent evolution and resolution in an acute inflammatory model of rat carrageenin-induced pleurisy
J. Leukoc. Biol., April 1, 2003; 73(4): 456 - 463.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Knapp, J. C. Leemans, S. Florquin, J. Branger, N. A. Maris, J. Pater, N. van Rooijen, and T. van der Poll
Alveolar Macrophages Have a Protective Antiinflammatory Role during Murine Pneumococcal Pneumonia
Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 171 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
T. Yamaryo, K. Oishi, H. Yoshimine, Y. Tsuchihashi, K. Matsushima, and T. Nagatake
Fourteen-Member Macrolides Promote the Phosphatidylserine Receptor-Dependent Phagocytosis of Apoptotic Neutrophils by Alveolar Macrophages
Antimicrob. Agents Chemother., January 1, 2003; 47(1): 48 - 53.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. H. Albertine, M. F. Soulier, Z. Wang, A. Ishizaka, S. Hashimoto, G. A. Zimmerman, M. A. Matthay, and L. B. Ware
Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
Am. J. Pathol., November 1, 2002; 161(5): 1783 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
L. Ottonello, M. Cutolo, G. Frumento, N. Arduino, M. Bertolotto, M. Mancini, E. Sottofattori, and F. Dallegri
Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines
Rheumatology, November 1, 2002; 41(11): 1249 - 1260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. E. Kilpatrick, J. Y. Lee, K. M. Haines, D. E. Campbell, K. E. Sullivan, and H. M. Korchak
A role for PKC-delta and PI 3-kinase in TNF-alpha -mediated antiapoptotic signaling in the human neutrophil
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C48 - C57.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G J Bellingan
The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS
Thorax, June 1, 2002; 57(6): 540 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
Y. Tsuchihashi, K. Oishi, H. Yoshimine, S. Suzuki, A. Kumatori, T. Sunazuka, S. Omura, K. Matsushima, and T. Nagatake
Fourteen-Member Macrolides Suppress Interleukin-8 Production but Do Not Promote Apoptosis of Activated Neutrophils
Antimicrob. Agents Chemother., April 1, 2002; 46(4): 1101 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Chello, P. Mastroroberto, A. Quirino, G. Cuda, F. Perticone, F. Cirillo, and E. Covino
Inhibition of neutrophil apoptosis after coronary bypass operation with cardiopulmonary bypass
Ann. Thorac. Surg., January 1, 2002; 73(1): 123 - 129.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. G. Kupfner, J. J. Arcaroli, H.-K. Yum, S. G. Nadler, K.-Y. Yang, and E. Abraham
Role of NF-{kappa}B in Endotoxemia-Induced Alterations of Lung Neutrophil Apoptosis
J. Immunol., December 15, 2001; 167(12): 7044 - 7051.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-K. Yum, J. Arcaroli, J. Kupfner, R. Shenkar, J. M. Penninger, T. Sasaki, K.-Y. Yang, J. S. Park, and E. Abraham
Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury
J. Immunol., December 1, 2001; 167(11): 6601 - 6608.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. Y. PARK, R. B. GOODMAN, K. P. STEINBERG, J. T. RUZINSKI, F. RADELLA II, D. R. PARK, J. PUGIN, S. J. SKERRETT, L. D. HUDSON, and T. R. MARTIN
Cytokine Balance in the Lungs of Patients with Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1896 - 1903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Fan, R. D. Ye, and A. B. Malik
Transcriptional mechanisms of acute lung injury
Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1037 - L1050.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. S. Filippatos, N. Gangopadhyay, O. Lalude, N. Parameswaran, S. I. Said, W. Spielman, and B. D. Uhal
Regulation of apoptosis by vasoactive peptides
Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L749 - L761.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Durand, Y. Renaudineau, J.-O. Pers, P. Youinou, and C. Jamin
Cross-Linking of Human Fc{gamma}RIIIb Induces the Production of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor by Polymorphonuclear Neutrophils
J. Immunol., October 1, 2001; 167(7): 3996 - 4007.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. OBERHOLZER, A. OBERHOLZER, M. CLARE-SALZLER, and L. L. MOLDAWER
Apoptosis in sepsis: a new target for therapeutic exploration
FASEB J, April 1, 2001; 15(6): 879 - 892.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. KITAMURA, S. HASHIMOTO, N. MIZUTA, A. KOBAYASHI, K. KOOGUCHI, I. FUJIWARA, and H. NAKAJIMA
Fas/FasL-dependent Apoptosis of Alveolar Cells after Lipopolysaccharide-induced Lung Injury in Mice
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 762 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. KURDOWSKA, J. M. NOBLE, K. P. STEINBERG, J. T. RUZINSKI, L. D. HUDSON, and T. R. MARTIN
Anti-interleukin 8 Autoantibody:Interleukin 8 Complexes in the Acute Respiratory Distress Syndrome . Relationship between the Complexes and Clinical Disease Activity
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 463 - 468.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. SITTIPUNT, K. P. STEINBERG, J. T. RUZINSKI, C. MYLES, S. ZHU, R. B. GOODMAN, L. D. HUDSON, S. MATALON, and T. R. MARTIN
Nitric Oxide and Nitrotyrosine in the Lungs of Patients with Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 503 - 510.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. MATUTE-BELLO, C. W. FREVERT, O. KAJIKAWA, S. J. SKERRETT, R. B. GOODMAN, D. R. PARK, and T. R. MARTIN
Septic Shock and Acute Lung Injury in Rabbits with Peritonitis . Failure of the Neutrophil Response to Localized Infection
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 234 - 243.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. J. FISHER, S. C. DONNELLY, N. HIRANI, C. HASLETT, R. M. STRIETER, J. H. DARK, and P. A. CORRIS
Elevated Levels of Interleukin-8 in Donor Lungs Is Associated with Early Graft Failure after Lung Transplantation
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 259 - 265.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
G. Matute-Bello, R. K. Winn, M. Jonas, E. Y. Chi, T. R. Martin, and W. C. Liles
Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo : Implications for Acute Pulmonary Inflammation
Am. J. Pathol., January 1, 2001; 158(1): 153 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. J. Leuenroth, P. S. Grutkoski, A. Ayala, and H. H. Simms
The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis
J. Leukoc. Biol., July 1, 2000; 68(1): 158 - 166.
[Abstract] [Full Text]

Home page
 ChestHome page
D. Droemann, S. P. Aries, F. Hansen, M. Moellers, J. Braun, H. A. Katus, and K. Dalhoff
Decreased Apoptosis and Increased Activation of Alveolar Neutrophils in Bacterial Pneumonia
Chest, June 1, 2000; 117(6): 1679 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 Chest