Am. J. Respir. Crit. Care Med., Volume 156, Number 2, August 1997, 536-541

Validation of the St. George's Respiratory Questionnaire in Bronchiectasis

CAROLYN B. WILSON, PAUL W. JONES, CATHERINE J. O'LEARY, PETER J. COLE, and ROBERT WILSON

Host Defence Unit, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, Division of Physiological Medicine, Department of Medicine, St. George's Hospital Medical School, London, United Kingdom

There is no disease-specific instrument available for health status assessment in bronchiectasis. We examined the stability, validity and responsiveness of a measure designed for asthma and COPD, the St. George's Respiratory Questionnaire (SGRQ), in this condition. One hundred and eleven patients were studied on 2 separate d 6 mo apart. On both days each patient completed the SGRQ and measures of general and disease-specific health, mood, and fatigue. They also performed a shuttle walking test and comprehensive lung function tests. Repeatability was tested over 2 wk in 23 patients. The intraclass correlation (r_I) for the SGRQ Total score was 0.97. The SGRQ component scores correlated well with relevant markers of disease activity. Examples include: SGRQ Symptoms score versus MRC Wheeze score, r = 0.634, p < 0.0001; Activity score versus shuttle walking test, r = 0.659, p < 0.0001; and Impacts score versus physical fatigue, r = 0.610, p < 0.0001. Changes in the SGRQ Total score from entry to follow-up also correlated with changes in other measures of the patients' health. There were significant differences in the SGRQ total score between patients who improved and those who deteriorated over the 6 mo in respect to wheeze (F = 5.6, p < 0.01) and breathlessness (F = 6.05, p < 0.01). We conclude that the SGRQ reflects impaired health in bronchiectasis patients.

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